Polio

Demonstration simulations for poliovirus type-2 transmission in Nigeria. The model structure was used to examine the impact Sabin vaccine reversion dynamics in contrast to nOPV vaccines.

Important features include:

• Multi-node network used to represent the country of Nigeria at either the admin-2 level or the 10km length scale.
• Network infectivity contagion transfer between nodes.
• Acquisition-transmission covariance.
• HINT structure to create non-participatory populations.
• Genome mutation dynamics and mutation labeling.
• Genome based variable infectivity.
• Clade labeling to create variable genome reversion trajectories.
• Immunity initialization from external data (IDM's Polio Immunity Mapper).
• Pre-specificed calendar of supplemental immunization activities (SIAs).
• Maternally derived immunity.
• Node-level variance in R0 value.
• Overdispersion of the infection rate.
• Maximum simulation duration based on elapsed time.
• Weighted agents to represent multiple individuals per agent.
• Population serosurveys implemented using custom reporters.