Ivermectin

The Ivermectin intervention class modifies the feeding outcome probabilities for both indoor- feeding and outdoor-feeding mosquitoes. It is an individually-distributed intervention that configures the waning of the drug’s killing effect on the adult mosquito population. This intervention enables exploration of the impact of giving humans an insecticidal drug, and how the effectiveness and duration of the drug’s killing-effect interacts with other interventions. For example, you can look at the impact of controlling and eliminating malaria transmission using both anti-parasite drugs that clear existing infections and insecticidal drugs.

Note

Parameters are case-sensitive. For Boolean parameters, set to 1 for true or 0 for false. Minimum, maximum, or default values of “NA” indicate that those values are not applicable for that parameter.

EMOD does not use true defaults; that is, if the dependency relationships indicate that a parameter is required, you must supply a value for it. However, many of the tools used to work with EMOD will use the default values provided below.

JSON format does not permit comments, but you can add “dummy” parameters to add contextual information to your files. Any keys that are not EMOD parameter names will be ignored by the model.

The table below describes all possible parameters with which this class can be configured. The JSON example that follows shows one potential configuration.

Parameter

Data type

Minimum

Maximum

Default

Description

Example

Cost_To_Consumer

float

0

999999

8

The unit cost per Ivermectin dosing (unamortized).

{
    "Cost_To_Consumer": 6.5
}

Disqualifying_Properties

array of strings

NA

NA

[]

A list of IndividualProperty key:value pairs that cause an intervention to be aborted (persistent interventions will stop being distributed to individuals with these values). See NodeProperties and IndividualProperties parameters for more information. Generally used to control the flow of health care access. For example, to prevent the same individual from accessing health care via two different routes at the same time.

{
    "Disqualifying_Properties": [
        "InterventionStatus:LostForever"
    ]
}

Dont_Allow_Duplicates

boolean

0

1

0

If an individual’s container has an intervention, set to true (1) to prevent them from receiving another copy of the intervention. Supported by all intervention classes.

{
    "Dont_Allow_Duplicates": 0
}

Intervention_Name

string

NA

NA

NA

The optional name used to refer to this intervention as a means to differentiate it from others that use the same class.

{
    "Intervention_Config": {
        "class": "Ivermectin",
        "Intervention_Name": "First distribution of ivermectin"
    }
}

Killing_Config

JSON object

NA

NA

NA

The configuration of Ivermectin killing efficacy and waning over time. Specify how this effect decays over time using one of the Waning effect classes.

{
    "Killing_Config": {
        "Box_Duration": 3650,
        "Initial_Effect": 0.53429,
        "class": "WaningEffectBox"
    }
}

New_Property_Value

string

NA

NA

NA

An optional IndividualProperty key:value pair that will be assigned when the intervention is distributed. See NodeProperties and IndividualProperties parameters for more information. Generally used to indicate the broad category of health care cascade to which an intervention belongs to prevent individuals from accessing care through multiple pathways. For example, if an individual must already be taking a particular medication to be prescribed a new one.

{
    "New_Property_Value": "InterventionStatus:None"
}
{
    "Events": [
        {
            "class": "CampaignEvent",
            "Nodeset_Config": {
                "class": "NodeSetAll"
            },
            "Start_Day": 120,
            "Event_Coordinator_Config": {
                "class": "StandardInterventionDistributionEventCoordinator",
                "Number_Repetitions": 5,
                "Target_Demographic": "Everyone",
                "Timesteps_Between_Repetitions": 3,
                "Demographic_Coverage": 0.8,
                "Intervention_Config": {
                    "class": "Ivermectin",
                    "Cost_To_Consumer": 1,
                    "Killing_Config": {
                        "Box_Duration": 3,
                        "Initial_Effect": 1,
                        "class": "WaningEffectBox"
                    }
                }
            }
        }
    ],
    "Use_Defaults": 1
}