BCGVaccine

The BCGVaccine intervention class includes vaccination in the simulation. Vaccination can reduce the likelihood of infection or transmission of pathogens. This intervention adds further functionality to vaccination by including the ability to vary vaccine take with age.

Note

Parameters are case-sensitive. For Boolean parameters, set to 1 for true or 0 for false. Minimum, maximum, or default values of “NA” indicate that those values are not applicable for that parameter.

EMOD does not use true defaults; that is, if the dependency relationships indicate that a parameter is required, you must supply a value for it. However, many of the tools used to work with EMOD will use the default values provided below.

JSON format does not permit comments, but you can add “dummy” parameters to add contextual information to your files. Any keys that are not EMOD parameter names will be ignored by the model.

The table below describes all possible parameters with which this class can be configured. The JSON example that follows shows one potential configuration.

Parameter

Data type

Minimum

Maximum

Default

Description

Example

Cost_To_Consumer

float

0

999999

10

The unit cost per vaccine (unamortized).

 
{
    "Cost_To_Consumer": 10.0
}

Disqualifying_Properties

array of strings

NA

NA

[]

A list of IndividualProperty key:value pairs that cause an intervention to be aborted (persistent interventions will stop being distributed to individuals with these values). See NodeProperties and IndividualProperties parameters for more information. Generally used to control the flow of health care access. For example, to prevent the same individual from accessing health care via two different routes at the same time.

 
{
    "Disqualifying_Properties": [
        "InterventionStatus:LostForever"
    ]
}

Dont_Allow_Duplicates

boolean

0

1

0

If an individual’s container has an intervention, set to true (1) to prevent them from receiving another copy of the intervention. Supported by all intervention classes.

 
{
    "Dont_Allow_Duplicates": 0
}

Efficacy_Is_Multiplicative

boolean

0

1

1

The overall vaccine efficacy when individuals receive more than one vaccine. When set to true (1), the vaccine efficacies are multiplied together; when set to false (0), the efficacies are additive.

 
{
    "Intervention_Config": {
        "class": "SimpleVaccine",
        "Cost_To_Consumer": 10,
        "Vaccine_Type": "AcquisitionBlocking",
        "Vaccine_Take": 1,
        "Efficacy_Is_Multiplicative": 0,
        "Waning_Config": {
            "class": "WaningEffectConstant",
            "Initial_Effect": 0.3
        }
    }
}

Intervention_Name

string

NA

NA

BCGVaccine

The optional name used to refer to this intervention as a means to differentiate it from others that use the same class.

 
{
    "Intervention_Config": {
        "class": "BCGVaccine",
        "Intervention_Name": "Routine TB vaccination"
    }
}

New_Property_Value

string

NA

NA

NA

An optional IndividualProperty key:value pair that will be assigned when the intervention is distributed. See NodeProperties and IndividualProperties parameters for more information. Generally used to indicate the broad category of health care cascade to which an intervention belongs to prevent individuals from accessing care through multiple pathways. For example, if an individual must already be taking a particular medication to be prescribed a new one.

 
{
    "New_Property_Value": "InterventionStatus:None"
}

Reduced_Transmit

float

0

1

1

The transmission reduction ratio, or the reduced infectiousness when an individual receives drugs.

 
{
    "Intervention_Config": {
        "Cost_To_Consumer": 1,
        "Drug_Type": "FirstLineCombo",
        "Durability_Profile": "FIXED_DURATION_CONSTANT_EFFECT",
        "Primary_Decay_Time_Constant": 10,
        "Remaining_Doses": 1,
        "TB_Drug_Cure_Rate": 0.1,
        "TB_Drug_Inactivation_Rate": 1e-08,
        "TB_Drug_Resistance_Rate": 1e-09,
        "TB_Drug_Relapse_Rate": 1e-07,
        "Reduced_Transmit": 1,
        "class": "AntiTBDrug"
    }
}

Vaccine_Take

float

0

1

1

The rate at which delivered vaccines will successfully stimulate an immune response and achieve the desired efficacy. For example, if it is set to 0.9, there will be a 90 percent chance that the vaccine will start with the specified efficacy, and a 10 percent chance that it will have no efficacy at all.

 
{
    "Intervention_Config": {
        "class": "SimpleVaccine",
        "Cost_To_Consumer": 10,
        "Vaccine_Type": "AcquisitionBlocking",
        "Vaccine_Take": 1,
        "Efficacy_Is_Multiplicative": 0,
        "Waning_Config": {
            "class": "WaningEffectConstant",
            "Initial_Effect": 0.3
        }
    }
}

Vaccine_Take_Age_Decay_Rate

float

-3.40282e+38

3.40282e+38

1

The exponential decline in vaccine take over time. The rate of decline is in units of 1/years.

 
{
    "Vaccine_Take_Age_Decay_Rate": 0.2
}

Vaccine_Type

enum

NA

NA

Generic

The type of vaccine to distribute in a vaccine intervention. Possible values are:

Generic

The vaccine can reduce transmission, acquisition, and mortality.

TransmissionBlocking

The vaccine will reduce pathogen transmission.

AcquisitionBlocking

The vaccine will reduce the acquisition of the pathogen by reducing the force of infection experienced by the vaccinated individual.

MortalityBlocking

The vaccine reduces the disease-mortality rate of a vaccinated individual.

 
{
    "Intervention_Config": {
        "class": "SimpleVaccine",
        "Cost_To_Consumer": 10,
        "Vaccine_Type": "AcquisitionBlocking",
        "Vaccine_Take": 1,
        "Efficacy_Is_Multiplicative": 0,
        "Waning_Config": {
            "class": "WaningEffectConstant",
            "Initial_Effect": 0.3
        }
    }
}

Waning_Config

JSON object

NA

NA

NA

The configuration of how the intervention efficacy wanes over time. Specify how this effect decays over time using one of the Waning effect classes.

 
{
    "Waning_Config": {
        "Box_Duration": 3650,
        "Initial_Effect": 1,
        "class": "WaningEffectBox"
    }
}

{
    "Events": [
        {
            "class": "CampaignEvent",
            "Event_Name": "vaccination for all new births",
            "Nodeset_Config": {
                "class": "NodeSetAll"
            },
            "Start_Day": 1,
            "Event_Coordinator_Config": {
                "class": "StandardInterventionDistributionEventCoordinator",
                "Number_Repetitions": 1,
                "Property_Restrictions": [],
                "Target_Demographic": "Everyone",
                "Demographic_Coverage": 1,
                "Intervention_Config": {
                    "class": "NodeLevelHealthTriggeredIV",
                    "Actual_IndividualIntervention_Config": {
                        "Cost_To_Consumer": 1,
                        "Vaccine_Take": 1,
                        "Vaccine_Take_Age_Decay_Rate": 0,
                        "Vaccine_Type": "AcquisitionBlocking",
                        "class": "BCGVaccine",
                        "Waning_Config": {
                            "class": "WaningEffectBox",
                            "Initial_Effect": 1,
                            "Box_Duration": 5475
                        }
                    },
                    "Trigger_Condition_List": [
                        "Births"
                    ]
                }
            }
        }
    ],
    "Use_Defaults": 1
}