Source code for hpvsim.calibration

Define the calibration class

import os
import numpy as np
import pylab as pl
import pandas as pd
import sciris as sc
from . import misc as hpm
from . import plotting as hppl
from . import analysis as hpa
from . import parameters as hppar
from .settings import options as hpo # For setting global options

__all__ = ['Calibration']

def import_optuna():
    ''' A helper function to import Optuna, which is an optional dependency '''
        import optuna as op # Import here since it's slow
    except ModuleNotFoundError as E: # pragma: no cover
        errormsg = f'Optuna import failed ({str(E)}), please install first (pip install optuna)'
        raise ModuleNotFoundError(errormsg)
    return op

[docs]class Calibration(sc.prettyobj): ''' A class to handle calibration of HPVsim simulations. Uses the Optuna hyperparameter optimization library (, which must be installed separately (via pip install optuna). Note: running a calibration does not guarantee a good fit! You must ensure that you run for a sufficient number of iterations, have enough free parameters, and that the parameters have wide enough bounds. Please see the tutorial on calibration for more information. Args: sim (Sim) : the simulation to calibrate datafiles (list) : list of datafile strings to calibrate to calib_pars (dict) : a dictionary of the parameters to calibrate of the format dict(key1=[best, low, high]) extra_sim_results (list) : list of result strings to store fit_args (dict) : a dictionary of options that are passed to sim.compute_fit() to calculate the goodness-of-fit par_samplers (dict) : an optional mapping from parameters to the Optuna sampler to use for choosing new points for each; by default, suggest_float n_trials (int) : the number of trials per worker n_workers (int) : the number of parallel workers (default: maximum total_trials (int) : if n_trials is not supplied, calculate by dividing this number by n_workers) name (str) : the name of the database (default: 'hpvsim_calibration') db_name (str) : the name of the database file (default: 'hpvsim_calibration.db') keep_db (bool) : whether to keep the database after calibration (default: false) storage (str) : the location of the database (default: sqlite) rand_seed (int) : if provided, use this random seed to initialize Optuna runs (for reproducibility) label (str) : a label for this calibration object die (bool) : whether to stop if an exception is encountered (default: false) verbose (bool) : whether to print details of the calibration kwargs (dict) : passed to hpv.Calibration() Returns: A Calibration object **Example**:: sim = hpv.Sim(pars, genotypes=[16, 18]) calib_pars = dict(beta=[0.05, 0.010, 0.20],hpv_control_prob=[.9, 0.5, 1]) calib = hpv.Calibration(sim, calib_pars=calib_pars, datafiles=['test_data/south_africa_hpv_data.xlsx', 'test_data/south_africa_cancer_data.xlsx'], total_trials=10, n_workers=4) calib.calibrate() calib.plot() ''' def __init__(self, sim, datafiles, calib_pars=None, genotype_pars=None, fit_args=None, extra_sim_results=None, par_samplers=None, n_trials=None, n_workers=None, total_trials=None, name=None, db_name=None, keep_db=None, storage=None, rand_seed=None, label=None, die=False, verbose=True): import multiprocessing as mp # Import here since it's also slow # Handle run arguments if n_trials is None: n_trials = 20 if n_workers is None: n_workers = mp.cpu_count() if name is None: name = 'hpvsim_calibration' if db_name is None: db_name = f'{name}.db' if keep_db is None: keep_db = False if storage is None: storage = f'sqlite:///{db_name}' if total_trials is not None: n_trials = int(np.ceil(total_trials/n_workers)) self.run_args = sc.objdict(n_trials=int(n_trials), n_workers=int(n_workers), name=name, db_name=db_name, keep_db=keep_db, storage=storage, rand_seed=rand_seed) # Handle other inputs self.label = label self.sim = sim self.calib_pars = calib_pars self.genotype_pars = genotype_pars self.extra_sim_results = extra_sim_results self.fit_args = sc.mergedicts(fit_args) self.par_samplers = sc.mergedicts(par_samplers) self.die = die self.verbose = verbose self.calibrated = False # Create age_results intervention self.target_data = [] for datafile in datafiles: self.target_data.append(hpm.load_data(datafile)) sim_results = sc.objdict() age_result_args = sc.objdict() extra_sim_results = sc.objdict() if self.extra_sim_results: for extra_result in self.extra_sim_results: extra_sim_results[extra_result] = sc.objdict() self.extra_sim_results_keys = extra_sim_results.keys() else: self.extra_sim_results_keys = None # Go through each of the target keys and determine how we are going to get the results from sim for targ in self.target_data: targ_keys = if len(targ_keys) > 1: errormsg = f'Only support one set of targets per datafile, {len(targ_keys)} provided' raise ValueError(errormsg) if 'age' in targ.columns: age_result_args[targ_keys[0]] = sc.objdict( datafile=sc.dcp(targ), compute_fit=True, ) else: sim_results[targ_keys[0]] = sc.objdict( data=sc.dcp(targ) ) ar = hpa.age_results(result_args=age_result_args) self.sim['analyzers'] += [ar] self.sim.initialize() for rkey in sim_results.keys(): sim_results[rkey].timepoints = sim.get_t(sim_results[rkey].data.year.unique()[0], return_date_format='str')[0]//sim.resfreq if 'weights' not in sim_results[rkey].data.columns: sim_results[rkey].weights = np.ones(len(sim_results[rkey].data)) self.age_results_keys = age_result_args.keys() self.sim_results = sim_results self.sim_results_keys = sim_results.keys() self.result_args = sc.objdict() for rkey in self.age_results_keys + self.sim_results_keys: self.result_args[rkey] = sc.objdict() self.result_args[rkey].name = self.sim.results[rkey].name self.result_args[rkey].color = self.sim.results[rkey].color if self.extra_sim_results: for rkey in self.extra_sim_results_keys: self.result_args[rkey] = sc.objdict() self.result_args[rkey].name = self.sim.results[rkey].name self.result_args[rkey].color = self.sim.results[rkey].color # Temporarily store a filename self.tmp_filename = 'tmp_calibration_%05i.obj' return
[docs] def run_sim(self, calib_pars=None, genotype_pars=None, label=None, return_sim=False): ''' Create and run a simulation ''' sim = self.sim.copy() if label: sim.label = label new_pars = self.get_full_pars(sim=sim, calib_pars=calib_pars, genotype_pars=genotype_pars) sim.update_pars(new_pars) # Run the sim try: if return_sim: return sim else: return except Exception as E: if self.die: raise E else: warnmsg = f'Encountered error running sim!\nParameters:\n{new_pars}\nTraceback:\n{sc.traceback()}' hpm.warn(warnmsg) output = None if return_sim else np.inf return output
[docs] @staticmethod def get_full_pars(sim=None, calib_pars=None, genotype_pars=None): ''' Make a full pardict from the subset of regular sim parameters and genotype parameters used in calibration''' # Prepare the parameters if calib_pars is not None: new_pars = {} for name, par in calib_pars.items(): if isinstance(par, dict): simpar =[name] for parkey, parval in par.items(): simpar[parkey] = parval new_pars[name] = simpar else: if name in new_pars[name] = par # new_pars = {k:v for k,v in calib_pars.items() if k in} if len(new_pars) != len(calib_pars): extra = set(calib_pars.keys()) - set(new_pars.keys()) errormsg = f'The following parameters are not part of the sim, nor is a custom function specified to use them: {sc.strjoin(extra)}' raise ValueError(errormsg) else: new_pars = {} if genotype_pars is not None: new_genotype_pars = {} for gname, gpars in genotype_pars.items(): this_genotype_pars = hppar.get_genotype_pars(gname) for gpar, gval in gpars.items(): if isinstance(gval, dict): for gparkey, gparval in gval.items(): this_genotype_pars[gpar][gparkey] = gparval else: this_genotype_pars[gpar] = gval new_genotype_pars[gname] = this_genotype_pars all_genotype_pars = sc.dcp(sim['genotype_pars']) all_genotype_pars.update(new_genotype_pars) new_pars['genotype_pars'] = all_genotype_pars return new_pars
[docs] def trial_pars_to_sim_pars(self, trial_pars=None, which_pars=None, return_full=True): ''' Create genotype_pars and pars dicts from the trial parameters. Note: not used during self.calibrate. Args: trial_pars (dict): dictionary of parameters from a single trial. If not provided, best parameters will be used return_full (bool): whether to return a unified par dict ready for use in a sim, or the sim pars and genotype pars separately **Example**:: sim = hpv.Sim(genotypes=[16, 18]) calib_pars = dict(beta=[0.05, 0.010, 0.20],hpv_control_prob=[.9, 0.5, 1]) genotype_pars = dict(hpv16=dict(prog_time=[3, 3, 10])) calib = hpv.Calibration(sim, calib_pars=calib_pars, genotype_pars=genotype_pars datafiles=['test_data/south_africa_hpv_data.xlsx', 'test_data/south_africa_cancer_data.xlsx'], total_trials=10, n_workers=4) calib.calibrate() new_pars = calib.trial_pars_to_sim_pars() # Returns best parameters from calibration in a format ready for sim running sim.update_pars(new_pars) ''' # Initialize calib_pars = {} genotype_pars = sc.objdict() # Deal with trial parameters if trial_pars is None: try: if which_pars is None or which_pars==0: trial_pars = self.best_pars else: ddict = self.df.to_dict(orient='records')[which_pars] trial_pars = {k:v for k,v in ddict.items() if k not in ['index','mismatch']} except: errormsg = 'No trial parameters provided.' raise ValueError(errormsg) # Handle genotype parameters for gname, gpars in self.genotype_pars.items(): this_genotype_pars = hppar.get_genotype_pars(gname) # Get default values for gpar, gval in gpars.items(): if isinstance(gval, dict): for gparkey in gval.keys(): this_genotype_pars[gpar][gparkey] = trial_pars[f'{gname}_{gpar}_{gparkey}'] # Update with values from trial pars else: this_genotype_pars[gpar] = trial_pars[f'{gname}_{gpar}'] genotype_pars[gname] = this_genotype_pars # Handle regular sim parameters for name, par in self.calib_pars.items(): if isinstance(par, dict): simpar =[name] for parkey in par.keys(): simpar[parkey] = trial_pars[f'{name}_{parkey}'] calib_pars[name] = simpar else: calib_pars[name] = trial_pars[name] # Return if return_full: all_pars = self.get_full_pars(sim=self.sim, calib_pars=calib_pars, genotype_pars=genotype_pars) return all_pars else: return calib_pars, genotype_pars
[docs] def sim_to_sample_pars(self): ''' Convert sim pars to sample pars ''' initial_pars = sc.objdict() par_bounds = sc.objdict() # Convert regular sim pars if self.calib_pars is not None: for key, val in self.calib_pars.items(): if isinstance(val, list): initial_pars[key] = val[0] par_bounds[key] = np.array([val[1], val[2]]) elif isinstance(val, dict): for parkey, par_highlowlist in val.items(): sampler_key = key + '_' + parkey + '_' initial_pars[sampler_key] = par_highlowlist[0] par_bounds[sampler_key] = np.array([par_highlowlist[1], par_highlowlist[2]]) # Convert genotype pars if self.genotype_pars is not None: for gname, gpardict in self.genotype_pars.items(): for key, val in gpardict.items(): if isinstance(val, list): sampler_key = gname + '_' + key initial_pars[sampler_key] = val[0] par_bounds[sampler_key] = np.array([val[1], val[2]]) elif isinstance(val, dict): for parkey, par_highlowlist in val.items(): sampler_key = gname + '_' + key + '_' + parkey initial_pars[sampler_key] = par_highlowlist[0] par_bounds[sampler_key] = np.array([par_highlowlist[1], par_highlowlist[2]]) return initial_pars, par_bounds
[docs] def trial_to_sim_pars(self, pardict=None, trial=None, gname=None): ''' Take in an optuna trial and sample from pars, after extracting them from the structure they're provided in ''' pars = {} for key, val in pardict.items(): if isinstance(val, list): low, high = val[1], val[2] if key in self.par_samplers: # If a custom sampler is used, get it now try: sampler_fn = getattr(trial, self.par_samplers[key]) except Exception as E: errormsg = 'The requested sampler function is not found: ensure it is a valid attribute of an Optuna Trial object' raise AttributeError(errormsg) from E else: sampler_fn = trial.suggest_float if gname is not None: sampler_key = gname + '_' + key else: sampler_key = key pars[key] = sampler_fn(sampler_key, low, high) # Sample from values within this range elif isinstance(val, dict): sampler_fn = trial.suggest_float pars[key] = dict() for parkey, par_highlowlist in val.items(): if gname is not None: sampler_key = gname + '_' + key + '_' + parkey else: sampler_key = key + '_' + parkey pars[key][parkey] = sampler_fn(sampler_key, par_highlowlist[1], par_highlowlist[2]) return pars
[docs] def run_trial(self, trial, save=True): ''' Define the objective for Optuna ''' if self.genotype_pars is not None: genotype_pars = {} for gname, pardict in self.genotype_pars.items(): genotype_pars[gname] = self.trial_to_sim_pars(pardict, trial, gname=gname) else: genotype_pars = None if self.calib_pars is not None: calib_pars = self.trial_to_sim_pars(self.calib_pars, trial) else: calib_pars = None sim = self.run_sim(calib_pars, genotype_pars, return_sim=True) # Compute fit for sim results and save sim results (TODO: THIS IS BY GENOTYPE FOR A SINGLE TIMEPOINT. GENERALIZE THIS) sim_results = sc.objdict() for rkey in self.sim_results: model_output = sim.results[rkey][:,self.sim_results[rkey].timepoints[0]] diffs = self.sim_results[rkey].data.value - model_output gofs = hpm.compute_gof(self.sim_results[rkey].data.value, model_output) losses = gofs * self.sim_results[rkey].weights mismatch = losses.sum() += mismatch sim_results[rkey] = model_output extra_sim_results = sc.objdict() if self.extra_sim_results: for rkey in self.extra_sim_results_keys: model_output = sim.results[rkey] extra_sim_results[rkey] = model_output # Store results in temporary files (TODO: consider alternatives) if save: results = dict(sim=sim_results, analyzer=sim.get_analyzer().results, extra_sim_results=extra_sim_results) filename = self.tmp_filename % trial.number, results) return
[docs] def worker(self): ''' Run a single worker ''' op = import_optuna() if self.verbose: op.logging.set_verbosity(op.logging.DEBUG) else: op.logging.set_verbosity(op.logging.ERROR) study = op.load_study(, output = study.optimize(self.run_trial, n_trials=self.run_args.n_trials, callbacks=None) # [tesst] return output
[docs] def run_workers(self): ''' Run multiple workers in parallel ''' if self.run_args.n_workers > 1: # Normal use case: run in parallel output = sc.parallelize(self.worker, iterarg=self.run_args.n_workers) else: # Special case: just run one output = [self.worker()] return output
[docs] def remove_db(self): ''' Remove the database file if keep_db is false and the path exists. ''' try: op = import_optuna() op.delete_study(, if self.verbose: print(f'Deleted study {} in {}') except Exception as E: print('Could not delete study, skipping...') print(str(E)) if os.path.exists(self.run_args.db_name): os.remove(self.run_args.db_name) if self.verbose: print(f'Removed existing calibration {self.run_args.db_name}') return
[docs] def make_study(self): ''' Make a study, deleting one if it already exists ''' op = import_optuna() if not self.run_args.keep_db: self.remove_db() if self.run_args.rand_seed is not None: sampler = op.samplers.RandomSampler(self.run_args.rand_seed) sampler.reseed_rng() raise NotImplementedError('Implemented but does not work') else: sampler = None output = op.create_study(,, sampler=sampler) return output
[docs] def calibrate(self, calib_pars=None, genotype_pars=None, verbose=True, load=True, tidyup=True, **kwargs): ''' Actually perform calibration. Args: calib_pars (dict): if supplied, overwrite stored calib_pars verbose (bool): whether to print output from each trial kwargs (dict): if supplied, overwrite stored run_args (n_trials, n_workers, etc.) ''' op = import_optuna() # Load and validate calibration parameters if calib_pars is not None: self.calib_pars = calib_pars if genotype_pars is not None: self.genotype_pars = genotype_pars if (self.calib_pars is None) and (self.genotype_pars is None): errormsg = 'You must supply calibration parameters (calib_pars or genotype_pars) either when creating the calibration object or when calling calibrate().' raise ValueError(errormsg) self.run_args.update(kwargs) # Update optuna settings # Run the optimization t0 = sc.tic() self.make_study() self.run_workers() study = op.load_study(, self.best_pars = sc.objdict(study.best_params) self.elapsed = sc.toc(t0, output=True) # Collect analyzer results # Load a single sim sim = self.sim # TODO: make sure this is OK #sc.jsonpickle([0].user_attrs['jsonpickle_sim']) = sim['n_genotypes'] self.glabels = [g.upper() for g in sim['genotype_map'].values()] # Replace with something else, this is fragile self.analyzer_results = [] self.sim_results = [] if load: print('Loading saved results...') for trial in study.trials: n = trial.number try: filename = self.tmp_filename % trial.number results = sc.load(filename) self.sim_results.append(results['sim']) self.analyzer_results.append(results['analyzer']) self.extra_sim_results.append(results['extra_sim_results']) if tidyup: try: os.remove(filename) print(f' Removed temporary file {filename}') except Exception as E: errormsg = f'Could not remove {filename}: {str(E)}' print(errormsg) print(f' Loaded trial {n}') except Exception as E: errormsg = f'Warning, could not load trial {n}: {str(E)}' print(errormsg) # Compare the results self.initial_pars, self.par_bounds = self.sim_to_sample_pars() self.parse_study(study) # Tidy up self.calibrated = True if not self.run_args.keep_db: self.remove_db() return self
[docs] def parse_study(self, study): '''Parse the study into a data frame -- called automatically ''' best = study.best_params self.best_pars = best print('Making results structure...') results = [] n_trials = len(study.trials) failed_trials = [] for trial in study.trials: data = {'index':trial.number, 'mismatch': trial.value} for key,val in trial.params.items(): data[key] = val if data['mismatch'] is None: failed_trials.append(data['index']) else: results.append(data) print(f'Processed {n_trials} trials; {len(failed_trials)} failed') keys = ['index', 'mismatch'] + list(best.keys()) data = sc.objdict().make(keys=keys, vals=[]) for i,r in enumerate(results): for key in keys: if key not in r: warnmsg = f'Key {key} is missing from trial {i}, replacing with default' hpm.warn(warnmsg) r[key] = best[key] data[key].append(r[key]) = data self.df = pd.DataFrame.from_dict(data) self.df = self.df.sort_values(by=['mismatch']) # Sort return
[docs] def to_json(self, filename=None, indent=2, **kwargs): ''' Convert the data to JSON. ''' order = np.argsort(self.df['mismatch']) json = [] for o in order: row = self.df.iloc[o,:].to_dict() rowdict = dict(index=row.pop('index'), mismatch=row.pop('mismatch'), pars={}) for key,val in row.items(): rowdict['pars'][key] = val json.append(rowdict) self.json = json if filename: return sc.savejson(filename, json, indent=indent, **kwargs) else: return json
[docs] def plot(self, res_to_plot=None, fig_args=None, axis_args=None, data_args=None, show_args=None, do_save=None, fig_path=None, do_show=True, plot_type='sns.boxplot', **kwargs): ''' Plot the calibration results Args: res_to_plot (int): number of results to plot. if None, plot them all fig_args (dict): passed to pl.figure() axis_args (dict): passed to pl.subplots_adjust() data_args (dict): 'width', 'color', and 'offset' arguments for the data do_save (bool): whether to save fig_path (str or filepath): filepath to save to do_show (bool): whether to show the figure kwargs (dict): passed to ``hpv.options.with_style()``; see that function for choices ''' # Import Seaborn here since slow if sc.isstring(plot_type) and plot_type.startswith('sns'): import seaborn as sns if plot_type.split('.')[1]=='boxplot': extra_args=dict(boxprops=dict(alpha=.3), showfliers=False) else: extra_args = dict() plot_func = getattr(sns, plot_type.split('.')[1]) else: plot_func = plot_type extra_args = dict() # Handle inputs fig_args = sc.mergedicts(dict(figsize=(12,8)), fig_args) axis_args = sc.mergedicts(dict(left=0.08, right=0.92, bottom=0.08, top=0.92), axis_args) d_args = sc.objdict(sc.mergedicts(dict(width=0.3, color='#000000', offset=0), data_args)) show_args = sc.objdict(sc.mergedicts(dict(show=dict(tight=True, maximize=False)), show_args)) all_args = sc.objdict(sc.mergedicts(fig_args, axis_args, d_args, show_args)) # Pull out results to use analyzer_results = sc.dcp(self.analyzer_results) sim_results = sc.dcp(self.sim_results) # Get rows and columns if not len(analyzer_results) and not len(sim_results): errormsg = 'Cannot plot since no results were recorded)' raise ValueError(errormsg) else: all_dates = [[date for date in r.keys() if date != 'bins'] for r in analyzer_results[0].values()] dates_per_result = [len(date_list) for date_list in all_dates] other_results = len(sim_results[0].keys()) n_plots = sum(dates_per_result) + other_results n_rows, n_cols = sc.get_rows_cols(n_plots) # Initialize fig, axes = pl.subplots(n_rows, n_cols, **fig_args) for ax in axes.flat[n_plots:]: ax.set_visible(False) axes = axes.flatten() pl.subplots_adjust(**axis_args) # Pull out attributes that don't vary by run age_labels = sc.objdict() for resname,resdict in zip(self.age_results_keys, analyzer_results[0].values()): age_labels[resname] = [str(int(resdict['bins'][i])) + '-' + str(int(resdict['bins'][i + 1])) for i in range(len(resdict['bins']) - 1)] age_labels[resname].append(str(int(resdict['bins'][-1])) + '+') # determine how many results to plot if res_to_plot is not None: index_to_plot = self.df.iloc[0:res_to_plot, 0].values analyzer_results = [analyzer_results[i] for i in index_to_plot] sim_results = [sim_results[i] for i in index_to_plot] # Make the figure with hpo.with_style(**kwargs): plot_count = 0 for rn, resname in enumerate(self.age_results_keys): x = np.arange(len(age_labels[resname])) # the label locations for date in all_dates[rn]: # Initialize axis and data storage structures ax = axes[plot_count] bins = [] genotypes = [] values = [] # Pull out data thisdatadf = self.target_data[rn][(self.target_data[rn].year == float(date)) & (self.target_data[rn].name == resname)] unique_genotypes = thisdatadf.genotype.unique() # Start making plot if 'genotype' in resname: for g in range( glabel = self.glabels[g].upper() # Plot data if glabel in unique_genotypes: ydata = np.array(thisdatadf[thisdatadf.genotype == glabel].value) ax.scatter(x, ydata, color=self.result_args[resname].color[g], marker='s', label=f'Data - {glabel}') # Construct a dataframe with things in the most logical order for plotting for run_num, run in enumerate(analyzer_results): genotypes += [glabel]*len(x) bins += x.tolist() values += list(run[resname][date][g]) # Plot model modeldf = pd.DataFrame({'bins':bins, 'values':values, 'genotypes':genotypes}) ax = plot_func(ax=ax, x='bins', y='values', hue="genotypes", data=modeldf, **extra_args) else: # Plot data ydata = np.array(thisdatadf.value) ax.scatter(x, ydata, color=self.result_args[resname].color, marker='s', label='Data') # Construct a dataframe with things in the most logical order for plotting for run_num, run in enumerate(analyzer_results): bins += x.tolist() values += list(run[resname][date]) # Plot model modeldf = pd.DataFrame({'bins':bins, 'values':values}) ax = plot_func(ax=ax, x='bins', y='values', data=modeldf, color=self.result_args[resname].color, **extra_args) # Set title and labels ax.set_xlabel('Age group') ax.set_title(self.result_args[resname].name+', '+ date.replace('.0', '')) ax.legend() ax.set_xticks(x, age_labels[resname]) plot_count += 1 for rn, resname in enumerate(self.sim_results_keys): x = np.arange(len(self.glabels)) ax = axes[plot_count] bins = [] values = [] thisdatadf = self.target_data[rn+sum(dates_per_result)][self.target_data[rn + sum(dates_per_result)].name == resname] ydata = np.array(thisdatadf.value) ax.scatter(x, ydata,, marker='s', label='Data') # Construct a dataframe with things in the most logical order for plotting for run_num, run in enumerate(sim_results): bins += x.tolist() values += list(run[resname]) # Plot model modeldf = pd.DataFrame({'bins': bins, 'values': values}) ax = plot_func(ax=ax, x='bins', y='values', data=modeldf, **extra_args) # Set title and labels date = thisdatadf.year[0] ax.set_xlabel('Genotype') ax.set_title(self.result_args[resname].name + ', ' + str(date)) ax.legend() ax.set_xticks(x, self.glabels) plot_count += 1 return hppl.tidy_up(fig, do_save=do_save, fig_path=fig_path, do_show=do_show, args=all_args)