model_polio01

Demonstration simulations for poliovirus type-2 transmission in Nigeria. The model structure was used to examine the impact Sabin vaccine reversion dynamics in contrast to nOPV vaccines.

Important features include:

• Multi-node network used to represent the country of Nigeria at either the admin-2 level or the 10km length scale.

• Network infectivity contagion transfer between nodes.

• Acquisition-transmission covariance.

• HINT structure to create non-participatory populations.

• Genome mutation dynamics and mutation labeling.

• Genome based variable infectivity.

• Clade labeling to create variable genome reversion trajectories.

• Immunity initialization from external data (IDM’s Polio Immunity Mapper).

• Pre-specificed calendar of supplemental immunization activities (SIAs).

• Maternally derived immunity.

• Node-level variance in R0 value.

• Overdispersion of the infection rate.

• Maximum simulation duration based on elapsed time.

• Weighted agents to represent multiple individuals per agent.

• Population serosurveys implemented using custom reporters.