Drugs and treatments

The following parameters determine the efficacy of drugs and other treatments.

Note

Parameters are case-sensitive. For Boolean parameters, set to 1 for true or 0 for false. Minimum, maximum, or default values of “NA” indicate that those values are not applicable for that parameter.

EMOD does not use true defaults; that is, if the dependency relationships indicate that a parameter is required, you must supply a value for it. However, many of the tools used to work with EMOD will use the default values provided below.

JSON format does not permit comments, but you can add “dummy” parameters to add contextual information to your files. Any keys that are not EMOD parameter names will be ignored by the model.

Parameter

Data type

Minimum

Maximum

Default

Description

Example

ART_CD4_at_Initiation_Saturating_Reduction_in_Mortality

float

0

3.40E+38

350

The duration from ART enrollment to on-ART HIV-caused death increases with CD4 at ART initiation up to a threshold determined by this parameter value.

 
{
    "ART_CD4_at_Initiation_Saturating_Reduction_in_Mortality": 350
}

TB_Drug_Cure_Rate

float

0

1

1

The daily probability of TB cure in an individual with drug-sensitive TB under drug treatment.

 
{
    "TB_Drug_Params": {
        "BurninDrug": {
            "TB_Drug_Cure_Rate": 0.0111,
            "TB_Drug_Inactivation_Rate": 0,
            "TB_Drug_Mortality_Rate": 0.00162,
            "TB_Drug_Relapse_Rate": 0.00223,
            "TB_Drug_Resistance_Rate": 0
        }
    }
}

TB_Drug_Cure_Rate_HIV

float

0

1

1

The daily probability of active TB infection being cured in an HIV+ person under drug treatment.

 
{
    "TBHIV_Drug_Params": {
        "ACFDOTS": {
            "TB_Drug_Cure_Rate": 0.25,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Mortality_Rate_HIV": 1e-09,
            "TB_Drug_Mortality_Rate_MDR": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Relapse_Rate_HIV": 1e-09,
            "TB_Drug_Relapse_Rate_MDR": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09,
            "TB_Drug_Resistance_Rate_HIV": 1e-09,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 1,
            "TB_Drug_Cure_Rate_HIV": 0,
            "TB_Drug_Cure_Rate_MDR": 0
        },
        "DOTSHQ": {
            "TB_Drug_Cure_Rate": 0.008,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 0.00038,
            "TB_Drug_Mortality_Rate_HIV": 0.00038,
            "TB_Drug_Mortality_Rate_MDR": 0.0008,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 0.00089,
            "TB_Drug_Relapse_Rate_HIV": 0.00089,
            "TB_Drug_Relapse_Rate_MDR": 0.001,
            "TB_Drug_Resistance_Rate": 0.0001,
            "TB_Drug_Resistance_Rate_HIV": 0.0001,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 0.5,
            "TB_Drug_Cure_Rate_HIV": 0.0004,
            "TB_Drug_Cure_Rate_MDR": 0.0004
        }
    }
}

TB_Drug_Cure_Rate_MDR

float

0

1

1

The daily probability of active MDR infection being cured in an HIV+ or HIV- person under drug treatment.

 
{
    "TBHIV_Drug_Params": {
        "ACFDOTS": {
            "TB_Drug_Cure_Rate": 0.25,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Mortality_Rate_HIV": 1e-09,
            "TB_Drug_Mortality_Rate_MDR": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Relapse_Rate_HIV": 1e-09,
            "TB_Drug_Relapse_Rate_MDR": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09,
            "TB_Drug_Resistance_Rate_HIV": 1e-09,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 1,
            "TB_Drug_Cure_Rate_HIV": 0,
            "TB_Drug_Cure_Rate_MDR": 0
        },
        "DOTSHQ": {
            "TB_Drug_Cure_Rate": 0.008,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 0.00038,
            "TB_Drug_Mortality_Rate_HIV": 0.00038,
            "TB_Drug_Mortality_Rate_MDR": 0.0008,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 0.00089,
            "TB_Drug_Relapse_Rate_HIV": 0.00089,
            "TB_Drug_Relapse_Rate_MDR": 0.001,
            "TB_Drug_Resistance_Rate": 0.0001,
            "TB_Drug_Resistance_Rate_HIV": 0.0001,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 0.5,
            "TB_Drug_Cure_Rate_HIV": 0.0004,
            "TB_Drug_Cure_Rate_MDR": 0.0004
        }
    }
}

TB_Drug_Efficacy_Multiplier_Failed

float

0

1

1

The scale factor for drug efficacy parameters (TB_Drug_Inactivation_Rate and TB_Drug_Cure_Rate) to give the efficacy of first-line drugs when given to individuals who have failed treatment.

 
{
    "TB_Drug_Efficacy_Multiplier_Failed": 1.0
}

TB_Drug_Efficacy_Multiplier_MDR

float

0

1

1

The scale factor for drug efficacy parameters (TB_Drug_Inactivation_Rate and TB_Drug_Cure_Rate) to give the efficacy of first-line drugs when given to individuals with MDR-TB.

 
{
    "TB_Drug_Efficacy_Multiplier_MDR": 1.0
}

TB_Drug_Efficacy_Multiplier_Relapsed

float

0

1

1

The scale factor for drug efficacy parameters (TB_Drug_Inactivation_Rate and TB_Drug_Cure_Rate) to give the efficacy of first-line drugs when given to individuals who have relapsed after treatment.

 
{
    "TB_Drug_Efficacy_Multiplier_Relapsed": 1.0
}

TB_Drug_Inactivation_Rate

float

0

1

1

The daily rate at which treatment with an anti-TB drug causes inactivation in an individual with drug-sensitive TB.

 
{
    "TB_Drug_Params": {
        "BurninDrug": {
            "TB_Drug_Cure_Rate": 0.0111,
            "TB_Drug_Inactivation_Rate": 0,
            "TB_Drug_Mortality_Rate": 0.00162,
            "TB_Drug_Relapse_Rate": 0.00223,
            "TB_Drug_Resistance_Rate": 0
        }
    }
}

TB_Drug_Inactivation_Rate_HIV

float

0

1

1

The daily probability of active drug-sensitive TB infection becoming latent in HIV+ person, not currently on ART, under drug treatment.

 
{
    "TBHIV_Drug_Params": {
        "ACFDOTS": {
            "TB_Drug_Cure_Rate": 0.25,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Mortality_Rate_HIV": 1e-09,
            "TB_Drug_Mortality_Rate_MDR": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Relapse_Rate_HIV": 1e-09,
            "TB_Drug_Relapse_Rate_MDR": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09,
            "TB_Drug_Resistance_Rate_HIV": 1e-09,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 1,
            "TB_Drug_Cure_Rate_HIV": 0,
            "TB_Drug_Cure_Rate_MDR": 0
        },
        "DOTSHQ": {
            "TB_Drug_Cure_Rate": 0.008,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 0.00038,
            "TB_Drug_Mortality_Rate_HIV": 0.00038,
            "TB_Drug_Mortality_Rate_MDR": 0.0008,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 0.00089,
            "TB_Drug_Relapse_Rate_HIV": 0.00089,
            "TB_Drug_Relapse_Rate_MDR": 0.001,
            "TB_Drug_Resistance_Rate": 0.0001,
            "TB_Drug_Resistance_Rate_HIV": 0.0001,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 0.5,
            "TB_Drug_Cure_Rate_HIV": 0.0004,
            "TB_Drug_Cure_Rate_MDR": 0.0004
        }
    }
}

TB_Drug_Inactivation_Rate_MDR

float

0

1

1

The daily probability of active MDR infection becoming latent in an HIV+ or HIV- person under drug treatment.

 
{
    "TBHIV_Drug_Params": {
        "ACFDOTS": {
            "TB_Drug_Cure_Rate": 0.25,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Mortality_Rate_HIV": 1e-09,
            "TB_Drug_Mortality_Rate_MDR": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Relapse_Rate_HIV": 1e-09,
            "TB_Drug_Relapse_Rate_MDR": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09,
            "TB_Drug_Resistance_Rate_HIV": 1e-09,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 1,
            "TB_Drug_Cure_Rate_HIV": 0,
            "TB_Drug_Cure_Rate_MDR": 0
        },
        "DOTSHQ": {
            "TB_Drug_Cure_Rate": 0.008,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 0.00038,
            "TB_Drug_Mortality_Rate_HIV": 0.00038,
            "TB_Drug_Mortality_Rate_MDR": 0.0008,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 0.00089,
            "TB_Drug_Relapse_Rate_HIV": 0.00089,
            "TB_Drug_Relapse_Rate_MDR": 0.001,
            "TB_Drug_Resistance_Rate": 0.0001,
            "TB_Drug_Resistance_Rate_HIV": 0.0001,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 0.5,
            "TB_Drug_Cure_Rate_HIV": 0.0004,
            "TB_Drug_Cure_Rate_MDR": 0.0004
        }
    }
}

TB_Drug_Mortality_Rate

float

0

1

0

The daily rate at which treatment with an anti-TB drug causes death in an individual with drug-sensitive TB.

 
{
    "TB_Drug_Params": {
        "BurninDrug": {
            "TB_Drug_Cure_Rate": 0.0111,
            "TB_Drug_Inactivation_Rate": 0,
            "TB_Drug_Mortality_Rate": 0.00162,
            "TB_Drug_Relapse_Rate": 0.00223,
            "TB_Drug_Resistance_Rate": 0
        }
    }
}

TB_Drug_Mortality_Rate_HIV

float

0

1

0

The daily probability of death for HIV+ individual with drug sensitive active infection under drug treatment.

 
{
    "TBHIV_Drug_Params": {
        "ACFDOTS": {
            "TB_Drug_Cure_Rate": 0.25,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Mortality_Rate_HIV": 1e-09,
            "TB_Drug_Mortality_Rate_MDR": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Relapse_Rate_HIV": 1e-09,
            "TB_Drug_Relapse_Rate_MDR": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09,
            "TB_Drug_Resistance_Rate_HIV": 1e-09,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 1,
            "TB_Drug_Cure_Rate_HIV": 0,
            "TB_Drug_Cure_Rate_MDR": 0
        },
        "DOTSHQ": {
            "TB_Drug_Cure_Rate": 0.008,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 0.00038,
            "TB_Drug_Mortality_Rate_HIV": 0.00038,
            "TB_Drug_Mortality_Rate_MDR": 0.0008,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 0.00089,
            "TB_Drug_Relapse_Rate_HIV": 0.00089,
            "TB_Drug_Relapse_Rate_MDR": 0.001,
            "TB_Drug_Resistance_Rate": 0.0001,
            "TB_Drug_Resistance_Rate_HIV": 0.0001,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 0.5,
            "TB_Drug_Cure_Rate_HIV": 0.0004,
            "TB_Drug_Cure_Rate_MDR": 0.0004
        }
    }
}

TB_Drug_Mortality_Rate_MDR

float

0

1

0

The daily probability of death for individual with MDR active infection under drug treatment.

 
{
    "TB_Drug_Mortality_Rate_MDR": 0
}

TB_Drug_Primary_Decay_Time_Constant

float

0

100000

0

The number of days before the efficacy of a specific anti-TB drug begins to decay.

 
{
    "TB_Drug_Params": {
        "CDCDrug": {
            "TB_Drug_Cure_Rate": 0.1,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 180.0,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09
        }
    }
}

TB_Drug_Relapse_Rate

float

0

1

0

The daily probability of TB inactivation and subsequent relapse in an individual with drug-sensitive TB under drug treatment.

 
{
    "TB_Drug_Params": {
        "CDCDrug": {
            "TB_Drug_Cure_Rate": 0.1,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 180.0,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09
        }
    }
}

TB_Drug_Relapse_Rate_HIV

float

0

1

0

The daily probability that a drug-sensitive active infection in an HIV+ individual not currently on ART will inactivate but subsequently relapse under drug treatment.

 
{
    "TBHIV_Drug_Params": {
        "ACFDOTS": {
            "TB_Drug_Cure_Rate": 0.25,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Mortality_Rate_HIV": 1e-09,
            "TB_Drug_Mortality_Rate_MDR": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Relapse_Rate_HIV": 1e-09,
            "TB_Drug_Relapse_Rate_MDR": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09,
            "TB_Drug_Resistance_Rate_HIV": 1e-09,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 1,
            "TB_Drug_Cure_Rate_HIV": 0,
            "TB_Drug_Cure_Rate_MDR": 0
        },
        "DOTSHQ": {
            "TB_Drug_Cure_Rate": 0.008,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 0.00038,
            "TB_Drug_Mortality_Rate_HIV": 0.00038,
            "TB_Drug_Mortality_Rate_MDR": 0.0008,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 0.00089,
            "TB_Drug_Relapse_Rate_HIV": 0.00089,
            "TB_Drug_Relapse_Rate_MDR": 0.001,
            "TB_Drug_Resistance_Rate": 0.0001,
            "TB_Drug_Resistance_Rate_HIV": 0.0001,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 0.5,
            "TB_Drug_Cure_Rate_HIV": 0.0004,
            "TB_Drug_Cure_Rate_MDR": 0.0004
        }
    }
}

TB_Drug_Relapse_Rate_MDR

float

0

1

0

The daily probability that an active MDR TB infection (in HIV+ or HIV-) will inactivate but subsequently relapse under drug treatment.

 
{
    "TBHIV_Drug_Params": {
        "ACFDOTS": {
            "TB_Drug_Cure_Rate": 0.25,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Mortality_Rate_HIV": 1e-09,
            "TB_Drug_Mortality_Rate_MDR": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Relapse_Rate_HIV": 1e-09,
            "TB_Drug_Relapse_Rate_MDR": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09,
            "TB_Drug_Resistance_Rate_HIV": 1e-09,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 1,
            "TB_Drug_Cure_Rate_HIV": 0,
            "TB_Drug_Cure_Rate_MDR": 0
        },
        "DOTSHQ": {
            "TB_Drug_Cure_Rate": 0.008,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 0.00038,
            "TB_Drug_Mortality_Rate_HIV": 0.00038,
            "TB_Drug_Mortality_Rate_MDR": 0.0008,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 0.00089,
            "TB_Drug_Relapse_Rate_HIV": 0.00089,
            "TB_Drug_Relapse_Rate_MDR": 0.001,
            "TB_Drug_Resistance_Rate": 0.0001,
            "TB_Drug_Resistance_Rate_HIV": 0.0001,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 0.5,
            "TB_Drug_Cure_Rate_HIV": 0.0004,
            "TB_Drug_Cure_Rate_MDR": 0.0004
        }
    }
}

TB_Drug_Resistance_Rate

float

0

1

0

The daily probability that an individual with drug-sensitive TB will acquire MDR-TB under drug treatment. Only individuals who return to the latent state or fail can acquire MDR-TB.

 
{
    "TB_Drug_Params": {
        "CDCDrug": {
            "TB_Drug_Cure_Rate": 0.1,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 180.0,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09
        }
    }
}

TB_Drug_Resistance_Rate_HIV

float

0

1

0

The daily probability that an (HIV+) individual with drug-sensitive TB will acquire MDR-TB under drug treatment. Only individuals who return to the latent state or fail can acquire MDR-TB.

 
{
    "TBHIV_Drug_Params": {
        "ACFDOTS": {
            "TB_Drug_Cure_Rate": 0.25,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Mortality_Rate_HIV": 1e-09,
            "TB_Drug_Mortality_Rate_MDR": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Relapse_Rate_HIV": 1e-09,
            "TB_Drug_Relapse_Rate_MDR": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09,
            "TB_Drug_Resistance_Rate_HIV": 1e-09,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 1,
            "TB_Drug_Cure_Rate_HIV": 0,
            "TB_Drug_Cure_Rate_MDR": 0
        },
        "DOTSHQ": {
            "TB_Drug_Cure_Rate": 0.008,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate_HIV": 1e-09,
            "TB_Drug_Inactivation_Rate_MDR": 1e-09,
            "TB_Drug_Mortality_Rate": 0.00038,
            "TB_Drug_Mortality_Rate_HIV": 0.00038,
            "TB_Drug_Mortality_Rate_MDR": 0.0008,
            "TB_Drug_Primary_Decay_Time_Constant": 179,
            "TB_Drug_Relapse_Rate": 0.00089,
            "TB_Drug_Relapse_Rate_HIV": 0.00089,
            "TB_Drug_Relapse_Rate_MDR": 0.001,
            "TB_Drug_Resistance_Rate": 0.0001,
            "TB_Drug_Resistance_Rate_HIV": 0.0001,
            "TB_Reduced_Acquire": 1,
            "TB_Reduced_Transmit": 0.5,
            "TB_Drug_Cure_Rate_HIV": 0.0004,
            "TB_Drug_Cure_Rate_MDR": 0.0004
        }
    }
}

TBHIV_Drug_Params

JSON object

NA

NA

NA

This JSON structure contains the names of anti-tuberculosis drugs and the parameters that define their efficacy. When you use the drugs in an intervention, you will refer to the drug name in the parameter Drug_Type or Drug_Type_by_Property.

The sum of all daily probabilities for state changes (for example, active to cured) and the total duration of treatment specify the probability that any event occurs. If no event occurs, the individual fails drug treatment.

 
{
    "TB_Drug_Params": {
        "CDCDrug": {
            "TB_Drug_Cure_Rate": 0.1,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 180.0,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09
        },
        "CDCDrugMDR": {
            "TB_Drug_Cure_Rate": 1e-09,
            "TB_Drug_Inactivation_Rate": 1e-09,
            "TB_Drug_Mortality_Rate": 1e-09,
            "TB_Drug_Primary_Decay_Time_Constant": 180.0,
            "TB_Drug_Relapse_Rate": 1e-09,
            "TB_Drug_Resistance_Rate": 1e-09
        }
    }
}

TBHIV_Drug_Types

array of strings

NA

NA

[]

The list of drug types that will be used with the TBHIVConfigurableTBdrug intervention. The values for each drug type are defined by TBHIV_Drug_Params.

 
{
    "TB_Drug_Types": [
        "CDCDrug",
        "CDCDrugRetx",
        "CDCDrugMDR"
    ]
}