Solvers

The CMS software offers 16 different solvers. They can be categorized into the following categories. The best solver to use will depend up on the disease and data you are simulating. Note that all solver names are case-insensitive in their corresponding .cfg file. If you do not specify a solver, Gillespie (SSA) will be used.

• Exact methods
  • Gillespie (SSA)
  • GillespieFirstReaction
  • Gibson-Bruck next reaction
  • Hybrid SSA
• Approximate methods
  • BLeaping
  • RLeaping
  • Tau-leaping
• Spatial simulation methods
  • Diffusive finite state projection (DFSP)
  • FractionalDiffusion (FD)
  • TransportSSA (ISSA)
• Rare event probability estimation
  • Doubly weighted stochastic simulation algorithm (dwSSA)
  • State-dependent doubly weighted stochastic simulation algorithm (sdwSSA)
• Exploratory methods
  • ExitTimes
  • Midpoint tau-leaping
  • RLeapingFast
  • OptimalTransportSSA (OTSSA)