Ivermectin

The Ivermectin intervention class modifies the feeding outcome probabilities for both indoor- and outdoor-feeding mosquitoes. Ivermectin works by increasing the mortality of mosquitoes after they blood-feed on a human. It is an individually-distributed intervention that configures the waning of the drug’s killing effect on the adult mosquito population. This intervention enables exploration of the impact of giving humans an insecticidal drug, and how the effectiveness and duration of the drug’s killing-effect interacts with other interventions. For example, you can look at the impact of controlling and eliminating malaria transmission using both anti-parasite drugs that clear existing infections and insecticidal drugs.

At a glance:

• Distributed to: Individuals

• Serialized: Yes, if it has been distributed to a person.

• Uses insecticides: Yes. It can target specific species or other subgroups.

• Time-based expiration: No, but it will expire if the efficacy is below 0.00001.

• Purge existing: Yes. If a new intervention is added to to the individual, the existing intervention of the same name is removed when the new one is added.

• Vector killing contributes to: Indoor/Outdoor Die After Feeding

• Vector effects: Killing

• Vector sexes affected: Females only

• Vector life stage affected: Adult

Note

Parameters are case-sensitive. For Boolean parameters, set to 1 for true or 0 for false. Minimum, maximum, or default values of “NA” indicate that those values are not applicable for that parameter.

EMOD does not use true defaults; that is, if the dependency relationships indicate that a parameter is required, you must supply a value for it. However, many of the tools used to work with EMOD will use the default values provided below.

JSON format does not permit comments, but you can add “dummy” parameters to add contextual information to your files. Any keys that are not EMOD parameter names will be ignored by the model.

The table below describes all possible parameters with which this class can be configured. The JSON example that follows shows one potential configuration.

Parameter	Data type	Minimum	Maximum	Default	Description	Example
Cost_To_Consumer	float	0	999999	8	The unit cost per Ivermectin dosing (unamortized).	{ "Cost_To_Consumer": 6.5 }
Disqualifying_Properties	array of strings	NA	NA	[]	A list of IndividualProperty key:value pairs that cause an intervention to be aborted (persistent interventions will stop being distributed to individuals with these values). See NodeProperties and IndividualProperties parameters for more information. Generally used to control the flow of health care access. For example, to prevent the same individual from accessing health care via two different routes at the same time.	{ "Disqualifying_Properties": [ "InterventionStatus:LostForever" ] }
Dont_Allow_Duplicates	boolean	0	1	0	If an individual’s container has an intervention, set to true (1) to prevent them from receiving another copy of the intervention. Supported by all intervention classes.	{ "Dont_Allow_Duplicates": 0 }
Insecticide_Name	string	NA	NA	UNINITIALIZED STRING	The name of the insecticide defined in the configuration parameter Insecticides for this intervention. If insecticides are being used, this must be defined as one of those values; if they are not being used this can be empty. It cannot have a value if you did not configure the configuration parameter Insecticides.	{ "Insecticide_Name": "carbamate" }
Intervention_Name	string	NA	NA	Ivermectin	The optional name used to refer to this intervention as a means to differentiate it from others that use the same class.	{ "Intervention_Config": { "class": "Ivermectin", "Intervention_Name": "First distribution of ivermectin" } }
Killing_Config	json object	NA	NA	NA	The configuration of Ivermectin killing efficacy and waning over time. Specify how this effect decays over time using one of the Waning effect classes.	{ "Killing_Config": { "Box_Duration": 3650, "Initial_Effect": 0.53429, "class": "WaningEffectBox" } }
New_Property_Value	string	NA	NA	“”	An optional IndividualProperty key:value pair that will be assigned when the intervention is applied. See NodeProperties and IndividualProperties parameters for more information. Generally used to indicate the broad category of health care cascade to which an intervention belongs to prevent individuals from accessing care through multiple pathways. For example, if an individual must already be taking a particular medication to be prescribed a new one.	{ "New_Property_Value": "InterventionStatus:None" }

{
    "Events": [
        {
            "class": "CampaignEvent",
            "Nodeset_Config": {
                "class": "NodeSetAll"
            },
            "Start_Day": 120,
            "Event_Coordinator_Config": {
                "class": "StandardInterventionDistributionEventCoordinator",
                "Number_Repetitions": 5,
                "Target_Demographic": "Everyone",
                "Timesteps_Between_Repetitions": 3,
                "Demographic_Coverage": 0.8,
                "Intervention_Config": {
                    "class": "Ivermectin",
                    "Cost_To_Consumer": 1,
                    "Killing_Config": {
                        "Box_Duration": 3,
                        "Initial_Effect": 1,
                        "class": "WaningEffectBox"
                    }
                }
            }
        }
    ],
    "Use_Defaults": 1
}